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Article

The role of mutations in the cohesin complex in acute myeloid leukemia.

International journal of hematology - 1 Jan 2017

Mazumdar Claire, Majeti Ravindra

Abstract excerpt

Mutations in the members of the cohesin complex have recently been identified as early events in acute myeloid leukemia (AML) pathogenesis. Studies conducted by our lab and others have shown that cohesin mutations or knockdown of cohesin subunits impair hematopoietic differentiation and enforce stem cell programs in both human and mouse hematopoiesis. Furthermore, studies in both models demonstrated global...

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Share to Cell Cycle Proteins
Share to Chromatin
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohesins

Share to Gene Expression Regulation, Leukemic

Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 27796738
DOI: 10.1007/s12185-016-2119-7
PMCID: PMC5516647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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