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Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single-cell analyses

29 Aug 2024

Abstract excerpt

BACKGROUNDDonor cell engraftment is a prerequisite of successful allogeneic hematopoietic stem cell transplantation. Based on peripheral blood analyses, it is characterized by early myeloid recovery and T and B cell lymphopenia. However, cellular networks associated with bone marrow engraftment of allogeneic human cells have been poorly described.METHODSMass cytometry and CITE-Seq analyses were performed on bone...

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PMID: 39207851
DOI: 10.1172/jci180331

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