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Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation

17 Mar 2023

Abstract excerpt

Hematopoietic stem cell transplantation is an effective regenerative therapy for many malignant, inherited, or autoimmune diseases. However, our understanding of reconstituted hematopoiesis in transplant patients remains limited. Here, we uncover the reconstitution dynamics of human allogeneic hematopoietic stem and progenitor cells (HSPCs) at single-cell resolution after transplantation. Transplanted HSPCs...

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PMID: 36930730
DOI: 10.1126/sciimmunol.abn6429

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