Article

Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

2024-11-06

Abstract excerpt

The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment and are imperative for disease progression as well as recurrence during treatment-free remission (TFR). Here, we have generated high-resolution single-cell m...

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Literature Corpus work: 42b0ffd3-a843-57eb-9b04-9925a1d9c83d
DOI: 10.7554/elife.92074.3

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