Article

Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

2023-08-18

Abstract excerpt

The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment. The sustained presence, heterogeneity and evolvability of LSCs are imperative for disease progression as well as recurrence during treatment-free remission...

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Literature Corpus work: 1570bb5d-9697-5d77-98a4-2a87ed31daf4
DOI: 10.1101/2023.08.16.553504

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