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Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome

1 Aug 2020

Abstract excerpt

BACKGROUND: immunophenotypic stem cell compartment in which the leukaemia-initiating cells reside. Transcriptional dysregulation at the stem cell level is likely fundamental to disease onset and progression. METHODS: stem cells from CMML patients and healthy controls using the droplet-based, ultra-high-throughput 10x platform. FINDINGS: We found substantial inter- and intra-patient heterogeneity, with CMML stem...

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PMID: 32763828
DOI: 10.1016/j.ebiom.2020.102904

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