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Single cell multi-omics enables high-resolution identification and functional purification of human acute myeloid leukemia stem cells

2026-07-13

Abstract excerpt

<h4>Summary</h4> In human acute myeloid leukemia (AML), a sub-population of leukemia stem cells (LSCs) drive disease initiation, therapeutic resistance, and relapse. However, the lack of reliable markers to distinguish LSCs from bulk leukemia cells has impeded progress in studying LSC pathogenesis and developing meaningful LSC-specific diagnostics and therapeutics. Existing LSC gene signatures, derived from bulk...

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Literature Corpus work
5552b941-57cc-5fa2-839e-f556e8710be8
DOI
10.64898/2026.07.12.737989
Open publication

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