Article

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines

2023-12-13

Abstract excerpt

Continuous evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and monoclonal antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S 2 subunit, which folds as a spring-loaded fusion machinery. Here, we describe...

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Literature Corpus work: 48dec470-0651-5694-9997-0e0057cf1401
DOI: 10.1101/2023.12.12.571160

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