Article

Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

2020-07-30

Abstract excerpt

Development of effective preventative interventions against SARS-CoV-2, the etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein of SARS-CoV-2 is a key target for prophylactic measures as it is critical for the viral replication cycle and the primary target of neutralizing antibodies. We evaluated design elements previously shown for other coronavirus S protein-based vaccines to be s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa54b113-330d-5da5-979c-5b6c1ca8d582
DOI: 10.1101/2020.07.30.227470

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responsesDOI 10.1101/2020.07.30.227470Read

MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humansSemantic proximity Read

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccinesSemantic proximity Read

Ad26.COV2.S elicited neutralizing activity against Delta and other SARS-CoV-2 variants of concernSemantic proximity Read

The Chimeric Adenovirus(Ad5/35) Expressing Engineered Spike Protein Confers Immunity Against SARS-Cov-2 in Mice and Non-Human PrimatesSemantic proximity Read

DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in miceSemantic proximity Read

SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants.Semantic proximity Read

Immunogenicity of an Ad26-based SARS-CoV-2 Omicron Vaccine in Naïve Mice and SARS-CoV-2 Spike Pre-immune HamstersSemantic proximity Read

SARS‐CoV‐2 Spike Stem Protein Nanoparticles Elicited Broad ADCC and Robust Neutralization against Variants in MiceSemantic proximity Read

Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicitySemantic proximity Read

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogensSemantic proximity Read

Computationally designed multi-epitope vaccine construct targeting the SARS-CoV-2 spike protein elicits robust immune responses in silicoSemantic proximity Read

Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicitySemantic proximity Read