Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.

doi:10.1084/jem.20251805

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Article

Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.

The Journal of experimental medicine - 2 Feb 2026

Lettera Emanuele, Basso-Ricci Luca, Carsana Edoardo, Giannetti Kety, Tavella Teresa, Seffin Luca, Farina Giacomo, Gualandi Nicolò, Quaranta Pamela, Lo Furno Elena, Pacini Guido, Della Volpe Lucrezia, Kaufmann Kerstin B, Garcia-Prat Laura, Hernandez Raisa Jofra, Murison Alex, Aguilar-Navarro Alicia G, Beretta Stefano, Conti Anastasia, Flores-Figueroa Eugenia, Ometti Marco, Merelli Ivan, Aiuti Alessandro, Xie Stephanie Z, Scala Serena, Di Micco Raffaella

Abstract excerpt

Hematopoietic stem/progenitor cells (HSPC) aging has long been associated with myeloid skewing, reduced clonal output, and impaired regenerative capacity, but quantitative immunophenotypic and functional analysis across the human lifespan has been lacking. Here, we provide a comprehensive phenotypic, transcriptional, and functional dissection of human hematopoiesis from youth to advanced age. Although primitive...

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Identifiers

PMID: 41474970
DOI: 10.1084/jem.20251805
PMCID: PMC13248933

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