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Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the life span

26 Mar 2025

Abstract excerpt

ABSTRACT: Hematopoietic stem cells (HSCs) exhibit significant age-related phenotypic and functional alterations. Although single-cell technologies have elucidated age-related compositional changes, prospective identification of aging-associated HSC subsets has remained challenging. In this study, using clusterin (Clu)-green fluorescent protein (GFP) reporter mice, we demonstrated that Clu expression faithfully...

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PMID: 40132120
DOI: 10.1182/blood.2024025776

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