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Article

Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.

Nature genetics - 1 Oct 2024

Herms Albert, Colom Bartomeu, Piedrafita Gabriel, Kalogeropoulou Argyro, Banerjee Ujjwal, King Charlotte, Abby Emilie, Murai Kasumi, Caseda Irene, Fernandez-Antoran David, Ong Swee Hoe, Hall Michael W J, Bryant Christopher, Sood Roshan K, Fowler Joanna C, Pol Albert, Frezza Christian, Vanhaesebroeck Bart, Jones Philip H

Abstract excerpt

Oncogenic PIK3CA mutations generate large clones in aging human esophagus. Here we investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of transgenic mice. Expression of a heterozygous Pik3caH1047R mutation drives clonal expansion by tilting cell fate toward proliferation. CRISPR screening and inhibitor treatment of primary esophageal keratinocytes confirmed the PI3K-mTOR pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39169259
DOI: 10.1038/s41588-024-01891-8
PMCID: PMC11525199

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