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Article

Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source.

PloS one - 1 Jan 2012

Foster Rebecca, Griffin Sue, Grooby Suzanne, Feltell Ruth, Christopherson Cindy, Chang Monica, Sninsky John, Kwok Shirley, Torrance Chris

Abstract excerpt

Targeting tumour metabolism is becoming a major new area of pharmaceutical endeavour. Consequently, a systematic search to define whether there are specific energy source dependencies in tumours, and how these might be dictated by upstream driving genetic mutations, is required. The PI3K-AKT-mTOR signalling pathway has a seminal role in regulating diverse cellular processes including cell proliferation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23028762
DOI: 10.1371/journal.pone.0045061
PMCID: PMC3441563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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