Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

doi:10.1172/jci.insight.97422

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Article

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

JCI insight - 25 Jan 2018

Schofield Heather K, Zeller Jörg, Espinoza Carlos, Halbrook Christopher J, Del Vecchio Annachiara, Magnuson Brian, Fabo Tania, Cali Daylan Ayse Ece, Kovalenko Ilya, Lee Ho-Joon, Yan Wei, Feng Ying, Karim Saadia A, Kremer Daniel M, Kumar-Sinha Chandan, Lyssiotis Costas A, Ljungman Mats, Morton Jennifer P, Galbán Stefanie, Fearon Eric R, Pasca di Magliano Marina

Abstract excerpt

Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors. Genetically engineered mice have proven instrumental in studies of the contribution of individual genes to carcinogenesis. Oncogenic Kras mutations occur early during pancreatic carcinogenesis and are considered an initiating event. In...

Topics

Animals
Carcinogenesis
Carcinoma, Pancreatic Ductal
Cell Line, Tumor
Disease Models, Animal
Disease Progression
Humans
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Invasiveness

Pancreas

Pancreatic Neoplasms

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 29367463
DOI: 10.1172/jci.insight.97422
PMCID: PMC5821189

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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