Article

Oncogenic <i>PIK3CA</i> promotes cellular stemness in an allele dose-dependent manner

2018-12-13

Abstract excerpt

The PIK3CA gene, which encodes the p110α catalytic subunit of PI3-kinase (PI3K), is mutationally activated in cancer and in overgrowth disorders known as PIK3CA -related overgrowth spectrum (PROS). To determine the consequences of genetic PIK3CA activation in a developmental context of relevance to both PROS and cancer, we engineered isogenic human induced pluripotent stem cells (iPSCs) with heterozygous or hom...

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Literature Corpus work: 3637893b-8d44-57dd-b58c-59895ab60a48
DOI: 10.1101/495093

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