Article

<i>Notch1</i> mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

2021-06-18

Abstract excerpt

<h4>Summary</h4> NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age, but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations may promote clonal expansion but impede carcinogenesis 1–3 . Here we test this hypothesis. Visualizing and sequencing NOTCH1 mutant clones in aging normal human esophagus reveals frequent biallelic mutations that block NOTCH1 signaling....

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Literature Corpus work: 87ca0e6e-6574-5e4e-be4c-846b90cae3c2
DOI: 10.1101/2021.06.18.448956

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