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Article

Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.

Nature genetics - 1 Oct 2024

Herms Albert, Fernandez-Antoran David, Alcolea Maria P, Kalogeropoulou Argyro, Banerjee Ujjwal, Piedrafita Gabriel, Abby Emilie, Valverde-Lopez Jose Antonio, Ferreira Inês S, Caseda Irene, Bejar Maria T, Dentro Stefan C, Vidal-Notari Sara, Ong Swee Hoe, Colom Bartomeu, Murai Kasumi, King Charlotte, Mahbubani Krishnaa, Saeb-Parsy Kourosh, Lowe Alan R, Gerstung Moritz, Jones Philip H

Abstract excerpt

Aging epithelia are colonized by somatic mutations, which are subjected to selection influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed the study of this and other long-term biological processes. Here, we describe epithelioids, a facile, cost-effective method of culturing multiple mouse and human epithelia. Esophageal epithelioids self-maintain without passaging for at...

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Cell Culture Techniques
Cell Differentiation
Cell Proliferation
CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelial Cells

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PMID: 39313617
DOI: 10.1038/s41588-024-01875-8
PMCID: PMC11525200

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