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Article

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.

The Journal of cell biology - 5 Jun 2017

Riemer Pamela, Rydenfelt Mattias, Marks Matthias, van Eunen Karen, Thedieck Kathrin, Herrmann Bernhard G, Blüthgen Nils, Sers Christine, Morkel Markus

Abstract excerpt

Colorectal cancer is driven by cooperating oncogenic mutations. In this study, we use organotypic cultures derived from transgenic mice inducibly expressing oncogenic β-catenin and/or PIK3CAH1047R to follow sequential changes in cancer-related signaling networks, intestinal cell metabolism, and physiology in a three-dimensional environment mimicking tissue architecture. Activation of β-catenin alone results in...

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Source

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Identifiers

PMID: 28442534
DOI: 10.1083/jcb.201610058
PMCID: PMC5461020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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