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Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic <i>PIK3CA</i> mutant progenitors in the esophagus

2021-05-28

Abstract excerpt

<h4>Summary</h4> Normal human tissues progressively accumulate cells carrying mutations. Activating mutations in PIK3CA generate large clones in the aging human esophagus, but the underlying cellular mechanisms are unclear. Here, we tracked mutant PIK3CA esophageal progenitor cells in transgenic mice by lineage tracing. Expression of an activating heterozygous Pik3ca H1047R mutation in single progenitor cells...

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Literature Corpus work
deef6af4-2b02-503f-a35b-f37f848cc8e4
DOI
10.1101/2021.05.28.446104
Open publication

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Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic <i>PIK3CA</i> mutant progenitors in the esophagusDOI 10.1101/2021.05.28.446104
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