Article

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

2022-02-04

Abstract excerpt

<h4>Summary</h4> Aging normal human epithelia, such as the esophagus, accumulate a substantial burden of TP53 mutant clones. These are the origin of most esophageal squamous carcinomas, in which biallelic TP53 disruption is almost frequent. However, the cellular mechanisms by which p53 mutants colonize the esophagus and participate in the subsequent stages of transformation are unclear. Here we show that induc...

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Literature Corpus work: 570392ba-447d-5def-8505-73ab5ad6969d
DOI: 10.1101/2022.02.03.478951

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