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Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2025

Dalal Alex R, Pedroza Albert J, Kim Jennifer L, Gilles Casey, Gu Wenduo, Kusadokoro Sho, Shad Rohan, Mitchel Olivia, Jackson William, Hiesinger William, Berry Gerald J, MacFarlane Elena G, Quertermous Thomas, Cheng Paul, Fischbein Michael P

Abstract excerpt

BACKGROUND: Loeys-Dietz syndrome (LDS), caused by mutations in the TGF-β (transforming growth factor-β) signaling cascade, leads to aggressive thoracic aneurysms. While vascular smooth muscle cell (SMC) phenotype modulation has been implicated in thoracic aneurysm formation, we sought to characterize the role of cell state transitions in LDS aneurysm pathogenesis. METHODS: We performed single-cell transcriptomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40109260
DOI: 10.1161/ATVBAHA.124.322069
PMCID: PMC12018128

Genes

TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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