Article
Increased AID results in mutations at the CRLF2 locus implicated in Latin American ALL health disparities.
Nature communications - 27 Jul 2024
Rangel Valeria, Sterrenberg Jason N, Garawi Aya, Mezcord Vyanka, Folkerts Melissa L, Calderon Sabrina E, Garcia Yadhira E, Wang Jinglong, Soyfer Eli M, Eng Oliver S, Valerin Jennifer B, Tanjasiri Sora Park, Quintero-Rivera Fabiola, Seldin Marcus M, Masri Selma, Frock Richard L, Fleischman Angela G, Pannunzio Nicholas R
Abstract excerpt
Activation-induced cytidine deaminase (AID) is a B cell-specific mutator required for antibody diversification. However, it is also implicated in the etiology of several B cell malignancies. Evaluating the AID-induced mutation load in patients at-risk for certain blood cancers is critical in assessing disease severity and treatment options. We have developed a digital PCR (dPCR) assay that allows us to quantify...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.