Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity

Abstract excerpt

Hispanic/Latino (H/L) children and adolescents are 1.2–1.75 times more likely to develop acute lymphoblastic leukemia (ALL) than Non-Hispanic Whites (NHW) [ 1 ]. Once they develop ALL, H/L children have a 40% higher death-rate than NHW, after correcting for socioeconomic factors [ 2 ]. Although H/L children with B-ALL have a worse prognosis than non-H/L children, the biological basis for this health disparity is...

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