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An RNA editing fingerprint of cancer stem cell reprogramming

11 Feb 2015

Abstract excerpt

BACKGROUND: Deregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML). Inflammation-associated activation of ADAR1 occurs in leukemia stem cells specifically in the advanced, often drug-resistant stage of CML known as blast crisis. However, detection of...

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PMID: 25889244
DOI: 10.1186/s12967-014-0370-3

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