Article
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.
Cancer cell - 8 Sept 2009
Klemm Lars, Duy Cihangir, Iacobucci Ilaria, Kuchen Stefan, von Levetzow Gregor, Feldhahn Niklas, Henke Nadine, Li Zhiyu, Hoffmann Thomas K, Kim Yong-mi, Hofmann Wolf-Karsten, Jumaa Hassan, Groffen John, Heisterkamp Nora, Martinelli Giovanni, Lieber Michael R, Casellas Rafael, Müschen Markus
Abstract excerpt
Chronic myeloid leukemia (CML) is induced by BCR-ABL1 and can be effectively treated for many years with Imatinib until leukemia cells acquire drug resistance through BCR-ABL1 mutations and progress into fatal B lymphoid blast crisis (LBC). Despite its clinical significance, the mechanism of progression into LBC is unknown. Here, we show that LBC but not CML cells express the B cell-specific mutator enzyme AID....
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