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Mutations at BCL11B Exon 4 Associated with T Cell Acute Lymphoblastic Leukemia Are Facilitated by AID and Formation of Non-B DNA Conformations.

Molecular and cellular biology - 1 Jan 2024

Roy Urbi, Sharma Anju, Sharma Shivangi, Dahal Sumedha, Kumari Nitu, Desai Sagar Sanjiv, Kumari Susmita, Dixit Jyotika, Sharma M Arun, Nujoom Najma, Choudhary Bibha, Raghavan Sathees C

Abstract excerpt

One of the primary reasons behind the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL) is the deregulation of the transcription factor BCL11B. The exon 4 of BCL11B harbors several driver mutations, which abolishes its DNA-binding ability. The high frequency of C > T or G > A conversion in close vicinity of AID (Activation-induced cytidine deaminase)-hotspot motifs in the deregulated gene prompted us to...

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PMID: 39511874
DOI: 10.1080/10985549.2024.2419661
PMCID: PMC11583620

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