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Article

Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response

1 Dec 2022

Abstract excerpt

Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family may have off-target effects genome-wide, but its effects at pan-cancer level are not well elucidated. Here, we used different pan-cancer datasets, totaling more than 50,000 samples analyzed by whole-genome,...

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PMID: 36456685
DOI: 10.1038/s41698-022-00331-2

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