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Article

Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells.

The Journal of experimental medicine - 14 May 2007

Feldhahn Niklas, Henke Nadine, Melchior Kai, Duy Cihangir, Soh Bonaventure Ndikung, Klein Florian, von Levetzow Gregor, Giebel Bernd, Li Aihong, Hofmann Wolf-Karsten, Jumaa Hassan, Müschen Markus

Abstract excerpt

The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. ALL cells are derived from B cell precursors in most cases and typically carry rearranged immunoglobulin heavy chain (IGH) variable (V) region genes devoid of somatic mutations. Somatic hypermutation is restricted to mature germinal center B...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17485517
DOI: 10.1084/jem.20062662
PMCID: PMC2118573

Genes

ABL1
BCR
IGH
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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