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Article

Competition shapes the landscape of X-chromosome-linked genetic diversity.

Nature genetics - 1 Aug 2024

Buenaventura Teresa, Bagci Hakan, Patrascan Ilinca, Graham Joshua J, Hipwell Kelsey D, Oldenkamp Roel, King James W D, Urtasun Jesus, Young George, Mouzo Daniel, Gomez-Cabrero David, Rowland Benjamin D, Panne Daniel, Fisher Amanda G, Merkenschlager Matthias

Abstract excerpt

X chromosome inactivation (XCI) generates clonal heterogeneity within XX individuals. Combined with sequence variation between human X chromosomes, XCI gives rise to intra-individual clonal diversity, whereby two sets of clones express mutually exclusive sequence variants present on one or the other X chromosome. Here we ask whether such clones merely co-exist or potentially interact with each other to modulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39060501
DOI: 10.1038/s41588-024-01840-5
PMCID: PMC11319201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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