Article
Widespread monoallelic expression on human autosomes.
Science (New York, N.Y.) - 16 Nov 2007
Gimelbrant Alexander, Hutchinson John N, Thompson Benjamin R, Chess Andrew
Abstract excerpt
Monoallelic expression with random choice between the maternal and paternal alleles defines an unusual class of genes comprising X-inactivated genes and a few autosomal gene families. Using a genome-wide approach, we assessed allele-specific transcription of about 4000 human genes in clonal cell lines and found that more than 300 were subject to random monoallelic expression. For a majority of monoallelic genes,...
Topics
- Alleles
- Animals
- Apoptosis Regulatory Proteins
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Clone Cells
- DNA-Binding Proteins
- Death-Associated Protein Kinases
- Dosage Compensation, Genetic
- Female
- Gene Expression
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genotype
- Humans
- In Situ Hybridization, Fluorescence
- Polymerase Chain Reaction
- Trans-Activators