Article
Intragenomic Conflict and Immune Tolerance: Do Selfish X-Linked Alleles Drive Skewed X Chromosome Inactivation?
Genome biology and evolution - 1 Mar 2018
Roy Scott W
Abstract excerpt
In mammalian females, diploid somatic cells contain two X chromosomes, one of which is transcriptionally silenced, in a process termed X chromosome inactivation (XCI). Whereas XCI is largely random in placental females, many women exhibit skewed XCI (SXCI), in which the vast majority cells have the same X chromosome inactivated. SXCI has serious health consequences, associated with conditions ranging from...
Topics
- Alleles
- Alzheimer Disease
- Chromosomes, Human, X
- Evolution, Molecular
- Female
- Genes, X-Linked
- Humans
- Immune Tolerance
- Pregnancy
- X Chromosome Inactivation