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Article

Co-mutation landscape and its prognostic impact on newly diagnosed adult patients with NPM1-mutated de novo acute myeloid leukemia

22 Jul 2024

Abstract excerpt

Approximately 25–35% of adult patients with acute myeloid leukemia (AML) carries NPM1 mutation, which generally indicated a favorable outcome in the absence of FLT3-ITD mutation [ 1 ]. NPM1 mutations are absent in clonal hematopoiesis, and have been considered as AML initiating lesions [ 2 ]. Research on co-mutation characteristics of NPM1 -mutated patients concentrated on FLT3-ITD , which has been suggested to...

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PMID: 39039048
DOI: 10.1038/s41408-024-01103-w

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