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Machine Learning Allows the Identification of New Co-Mutational Patterns with Prognostic Implications in NPM1 Mutated AML - Results of the European Harmony Alliance

2022-11-15

Abstract excerpt

Background: Mutations of NPM1 are generally considered as a favorable prognostic marker in acute myeloid leukemia (AML), although patients present with distinct co-mutations that might influence outcomes. The recently updated European LeukemiaNet classification (ELN2022) does now group NPM1mut AML patients with FLT3-ITD (regardless of the allelic ratio) as intermediate prognosis, while NPM1mut without FLT3-ITD is...

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Acute Myeloid Leukemia Research

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Literature Corpus work: dd94808c-3395-5c7e-8e12-ccf17b92fe94
DOI: 10.1182/blood-2022-167138

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