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Article

Influence of genetic co-mutation on chemotherapeutic outcome in NPM1-mutated and FLT3-ITD wild-type AML patients.

Cancer medicine - 1 Aug 2024

Wu Quan, Zhang Yujiao, Yuan Baoyi, Huang Yun, Jiang Ling, Liu Fang, Yan Ping, Cheng Jiaying, Long Zhiquan, Jiang Xuejie

Abstract excerpt

BACKGROUND: Nucleophosmin 1 (NPM1) gene-mutated acute myeloid leukemia (NPM1mut AML) is classified as a subtype with a favorable prognosis. However, some patients fail to achieve a complete remission or relapse after intensified chemotherapy. Genetic abnormalities in concomitant mutations contribute to heterogeneous prognosis of NPM1mut AML patients. METHODS: In this study, 91 NPM1-mutated and FLT3-ITD wild-type...

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Identifiers

PMID: 39126219
DOI: 10.1002/cam4.70102
PMCID: PMC11316012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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