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The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML

30 May 2019

Abstract excerpt

Acute myeloid leukemia (AML) is a genetically heterogeneous disease with a clinical course predicted by recurrent cytogenetic abnormalities and/or gene mutations. The NPM1 insertion mutations define the largest distinct genetic subset, ∼30% of AML, and is considered a favorable risk marker if there is no (or low allelic ratio) FLT3 internal tandem duplication (FLT3 ITD) mutation. However, ∼40% of patients with...

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PMID: 31145495
DOI: 10.1002/ajh.25517

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