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Article

Coexisting and cooperating mutations in NPM1-mutated acute myeloid leukemia.

Leukemia research - 1 May 2017

Patel Jay L, Schumacher Jonathan A, Frizzell Kimberly, Sorrells Shelly, Shen Wei, Clayton Adam, Jattani Rakhi, Kelley Todd W

Abstract excerpt

NPM1 insertion mutations represent a common recurrent genetic abnormality in acute myeloid leukemia (AML) patients. The frequency of these mutations varies from approximately 30% overall up to 50% in patients with a normal karyotype. Several recent studies have exploited advances in massively parallel sequencing technology to shed light on the complex genomic landscape of AML. We hypothesize that variant allele...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28152414
DOI: 10.1016/j.leukres.2017.01.027

Genes

NPM1
FLT3
IDH1
IDH2
NRAS
PTPN11
RAD21
SMC3
SRSF2
STAG2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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