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Article

High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML.

Blood - 21 Jun 2018

Patel Sanjay S, Kuo Frank C, Gibson Christopher J, Steensma David P, Soiffer Robert J, Alyea Edwin P, Chen Yi-Bin A, Fathi Amir T, Graubert Timothy A, Brunner Andrew M, Wadleigh Martha, Stone Richard M, DeAngelo Daniel J, Nardi Valentina, Hasserjian Robert P, Weinberg Olga K

Abstract excerpt

Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 World Health Organization classification and is associated with a favorable prognosis. Although previous studies have evaluated NPM1 in a binary fashion, little is known about the significance of its mutant allele burden at diagnosis, nor has the effect of comutations (other than FLT3) been extensively...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29724895
DOI: 10.1182/blood-2018-01-828467
PMCID: PMC6265642

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML.PMID 29724895Read ↗

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