Article
Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study.
Leukemia - 1 Feb 2026
Hernández-Sánchez Alberto, Villaverde Ramiro Ángela, Sträng Eric, Turki Amin T, Abáigar María, Versluis Jurjen, Thomas Ian, Sobas Marta, Martínez Elicegui Javier, Castellani Gastone, Benner Axel, Azibeiro Raúl, Tettero Jesse M, Mecklenbrauck Rabea, Martínez-López Joaquín, Pratcorona Marta, Mills Ken I, Sanz Guillermo, Voso Maria Teresa, Sören Lehmann, Röllig Christoph, Thiede Christian, Metzeler Klaus H, Döhner Konstanze, Heuser Michael, Haferlach Torsten, Valk Peter Jm, Russell Nigel, Hernández-Rivas Jesús María, Huntly Brian, Ossenkoppele Gert, Döhner Hartmut, Bullinger Lars
Abstract excerpt
NPM1-mutated (NPM1-mut) acute myeloid leukemia (AML) is generally associated with a more favorable outcome, although the presence of additional gene mutations can influence patient prognosis. We analyzed intensively-treated adult NPM1-mut AML patients included in the HARMONY Alliance database. A newly developed risk classification, which included combinations of co-mutations in FLT3-ITD, DNMT3A, IDH1/IDH2, and...
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