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Article

Common polygenic variation in the early medication change (EMC) cohort affects disorder risk, but not the antidepressant treatment response.

Journal of affective disorders - 15 Oct 2024

Müller Svenja, Lieb Klaus, Streit Fabian, Awasthi Swapnil, Wagner Stefanie, Frank Josef, Müller Marianne B, Tadic André, Heilmann-Heimbach Stefanie, Hoffmann Per, Mavarani Laven, Schmidt Börge, Rietschel Marcella, Witt Stephanie H, Zillich Lea, Engelmann Jan

Abstract excerpt

BACKGROUND: Given the great interest in identifying reliable predictors of the response to antidepressant drugs, the present study investigated whether polygenic scores (PGS) for Major Depressive Disorder (MDD) and antidepressant treatment response (ADR) were related to the complex trait of antidepressant response in the Early Medication Change (EMC) cohort. METHODS: In this secondary analysis of the EMC trial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39038621
DOI: 10.1016/j.jad.2024.07.138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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