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Article

Polygenic risk scores in major depressive disorder: A systematic review across diagnostic, treatment, course/severity, and subtype domains.

Journal of affective disorders - 1 Dec 2026

Li Yang, Liu Rui, Guo Yijing, Xu Zhi

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) is heterogeneous across diagnostic, treatment-related, course/severity, and subtype domains. Polygenic risk score (PRS) studies have examined these domains, but differences in PRS sources, samples, methods, and endpoint definitions have fragmented the evidence. We synthesised findings and examined potential contributors to heterogeneity. METHODS: PubMed/MEDLINE, Embase,...

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Topics

Humans
Genetic Predisposition to Disease
Genetic Risk Score
Major Depressive Disorder
Multifactorial Inheritance
Severity of Illness Index

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Identifiers

PMID: 42537814
DOI: 10.1016/j.jad.2026.122335

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TRD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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