Article

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts

2018-04-05

Abstract excerpt

There are currently no reliable approaches for correctly identifying which patients with major depressive disorder (MDD) will respond well to antidepressant therapy. However, recent genetic advances suggest that Polygenic Risk Scores (PRS) could allow MDD patients to be stratified for antidepressant response. We used PRS for MDD and PRS for neuroticism as putative predictors of antidepressant response within three...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a1088c76-45ce-5c3f-b9de-3643767e049d
DOI: 10.1101/295717

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohortsDOI 10.1101/295717Read

A meta-analysis of polygenic risk scores for mood disorders, neuroticism, and schizophrenia in antidepressant response.Semantic proximity Read

A meta-analysis of polygenic risk scores for mood disorders, neuroticism, and schizophrenia in antidepressant responseSemantic proximity Read

Pharmacogenetics of antidepressant response: a polygenic approachSemantic proximity Read

Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression.Semantic proximity Read

Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder.Semantic proximity Read

Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorderSemantic proximity Read

Genetic risk scores of psychiatric phenotypes are associated with depression risk in a prospective Dutch population-based cohort.Semantic proximity Read

The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review.Semantic proximity Read

Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder.Semantic proximity Read

Exploring depression treatment response by using polygenic risk scoring across diverse populations.Semantic proximity Read

TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample.Semantic proximity Read

Polygenic Analyses Show Important Differences Between Major Depressive Disorder Symptoms Measured Using Various Instruments.Semantic proximity Read