Article
Therapy response prediction in major depressive disorder: current and novel genomic markers influencing pharmacokinetics and pharmacodynamics.
Pharmacogenomics - 1 Jun 2021
Shalimova Alena, Babasieva Viktoria, Chubarev Vladimir N, Tarasov Vadim V, Schiöth Helgi B, Mwinyi Jessica
Abstract excerpt
Major depressive disorder is connected with high rates of functional disability and mortality. About a third of the patients are at risk of therapy failure. Several pharmacogenetic markers especially located in CYP450 genes such as CYP2D6 or CYP2C19 are of relevance for therapy outcome prediction in major depressive disorder but a further optimization of predictive tools is warranted. The article summarizes the...
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