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Article

From pharmacokinetic genes to polygenic scores and multi-omic integration: advances toward precision psychiatry.

Expert opinion on drug metabolism & toxicology - 1 Jan 2026

Bellanca Carlo Maria, Squassina Alessio, Manchia Mirko, Paribello Pasquale, Fadda Paola, Bernardini Renato, Cantarella Giuseppina, Pisanu Claudia

Abstract excerpt

INTRODUCTION: Pharmacological treatment is the mainstay in the acute and long-term management of severe mental disorders such as major depressive disorder, schizophrenia, and bipolar disorder. However, there is large interindividual variability in clinical response, with around one-third of patients presenting treatment-resistance. AREAS COVERED: This review provides a comprehensive overview of genes that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41789450
DOI: 10.1080/17425255.2026.2639520

Genes

CYP2B6
CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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