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Article

Exploring depression treatment response by using polygenic risk scoring across diverse populations.

American journal of human genetics - 7 Aug 2025

Lapinska Sandra, Pimplaskar Aditya, Shi Zhuozheng, Ding Yi, Frydman-Gani Clara, Hou Kangcheng, Venkateswaran Vidhya, Boulier Kristin, Olde Loohuis Loes M, Pasaniuc Bogdan

Abstract excerpt

Treatment-resistant depression (TRD), usually defined as limited or no response to at least two antidepressants, occurs in approximately one-third of individuals diagnosed with major depressive disorder (MDD). Studies of individuals of European ancestry highlight a genetic overlap between TRD and MDD. We analyzed two large and diverse biobanks, the UCLA ATLAS Community Health Study (ATLAS) and the All of Us...

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Identifiers

PMID: 40580956
DOI: 10.1016/j.ajhg.2025.06.003
PMCID: PMC12362525

Genes

TRD

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