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A meta-analysis of polygenic risk scores for mood disorders, neuroticism, and schizophrenia in antidepressant response

2021-06-01

Abstract excerpt

About two-thirds of patients with major depressive disorder (MDD) fail to achieve symptom remission after the initial antidepressant treatment. Despite a role of genetic factors was proven, the specific underpinnings are not fully understood yet. Polygenic risk scores (PRSs), which summarise the additive effect of multiple risk variants across the genome, might provide insights into the underlying genetics. This s...

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Literature Corpus work
f51bd1d0-2069-55cf-b4c3-4d4ac8be66c3
DOI
10.1101/2021.05.28.21257812
Open publication

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A meta-analysis of polygenic risk scores for mood disorders, neuroticism, and schizophrenia in antidepressant responseDOI 10.1101/2021.05.28.21257812
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