A naturalistic retrospective evaluation of the utility of pharmacogenetic testing based on CYP2D6 e CYP2C19 profiling in antidepressants treatment in a cohort of patients with major depressive disorder.

doi:10.1016/j.pnpbp.2025.111292

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A naturalistic retrospective evaluation of the utility of pharmacogenetic testing based on CYP2D6 e CYP2C19 profiling in antidepressants treatment in a cohort of patients with major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Mar 2025

Squassina Alessio, Paribello Pasquale, Pinna Marco, Contu Martina, Pisanu Claudia, Congiu Donatella, Severino Giovanni, Meloni Anna, Carta Andrea, Conversano Claudio, Mola Francesco, Del Zompo Maria, d'Aversa Federico Bernoni, Minelli Alessandra, Gennarelli Massimo, Pinna Federica, Carpiniello Bernardo, Manchia Mirko

Abstract excerpt

Response to antidepressants (ADs) is highly variable and partly genetically driven, but the utility of pharmacogenetic testing in guiding ADs treatment is still controversial. We conducted a retrospective, naturalistic study to explore the utility of CYP2C6 and CYP2C19 genotyping in ADs treatment in a sample of 156 patients diagnosed with major depressive disorder from south Sardinia (Italy). Clinical data,...

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PMID: 39971121
DOI: 10.1016/j.pnpbp.2025.111292

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CYP2C19

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