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Article

Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes.

Genome medicine - 16 Jun 2022

Wang Meng, Banik Ishani, Shain A Hunter, Yeh Iwei, Bastian Boris C

Abstract excerpt

BACKGROUND: Acral and mucosal melanomas are aggressive subtypes of melanoma, which have a significantly lower burden of somatic mutations than cutaneous melanomas, but more frequent copy number variations, focused gene amplifications, and structural alterations. The landscapes of their genomic alterations remain to be fully characterized. METHODS: We compiled sequencing data of 240 human acral and mucosal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35706047
DOI: 10.1186/s13073-022-01068-0
PMCID: PMC9202124

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