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Article

Integrative splicing-quantitative-trait-locus analysis reveals risk loci for non-small-cell lung cancer.

American journal of human genetics - 7 Sept 2023

Wang Yuzhuo, Ding Yue, Liu Su, Wang Cheng, Zhang Erbao, Chen Congcong, Zhu Meng, Zhang Jing, Zhu Chen, Ji Mengmeng, Dai Juncheng, Jin Guangfu, Hu Zhibin, Shen Hongbing, Ma Hongxia

Abstract excerpt

Splicing quantitative trait loci (sQTLs) have been demonstrated to contribute to disease etiology by affecting alternative splicing. However, the role of sQTLs in the development of non-small-cell lung cancer (NSCLC) remains unknown. Thus, we performed a genome-wide sQTL study to identify genetic variants that affect alternative splicing in lung tissues from 116 individuals of Chinese ancestry, which resulted in...

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Adenocarcinoma of Lung
Alternative Splicing
Carcinoma, Non-Small-Cell Lung
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Identifiers

PMID: 37562399
DOI: 10.1016/j.ajhg.2023.07.008
PMCID: PMC10502736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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