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Article

Epistatic interaction between ERAP2 and HLA modulates HIV-1 adaptation and disease outcome in an Australian population.

PLoS pathogens - 1 Jul 2024

Al-Kaabi Marwah, Deshpande Pooja, Firth Martin, Pavlos Rebecca, Chopra Abha, Basiri Hamed, Currenti Jennifer, Alves Eric, Kalams Spyros, Fellay Jacques, Phillips Elizabeth, Mallal Simon, John Mina, Gaudieri Silvana

Abstract excerpt

A strong genetic predictor of outcome following untreated HIV-1 infection is the carriage of specific alleles of human leukocyte antigens (HLAs) that present viral epitopes to T cells. Residual variation in outcome measures may be attributed, in part, to viral adaptation to HLA-restricted T cell responses. Variants of the endoplasmic reticulum aminopeptidases (ERAPs) influence the repertoire of T cell epitopes...

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Topics

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Share to HIV Infections
Share to Aminopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epistasis, Genetic

Share to HLA Antigens

Share to Polymorphism, Single Nucleotide

Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 38980912
DOI: 10.1371/journal.ppat.1012359
PMCID: PMC11259285

Genes

ERAP2
CCR5
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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