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Article

Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection.

AIDS (London, England) - 17 Jul 2013

Biasin Mara, Sironi Manuela, Saulle Irma, de Luca Mariacristina, la Rosa Francesca, Cagliani Rachele, Forni Diego, Agliardi Cristina, lo Caputo Sergio, Mazzotta Francesco, Trabattoni Daria, Macias Juan, Pineda Juan A, Caruz Antonio, Clerici Mario

Abstract excerpt

OBJECTIVE: Haplotype-specific alternative splicing of the endoplasmic reticulum (ER) aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively spliced (AS, haplotype B) mRNA. As ERAP2 trims peptides loaded on major histocompatibility complex (MHC) class I and CD8 T lymphocytes protect against viral infections, we analysed its role in resistance to HIV-1 infection....

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Source

Identifiers

PMID: 23435305
DOI: 10.1097/QAD.0b013e3283601cee

Genes

ERAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection.PMID 23435305Read ↗

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